Ali Haidar, Hatim Essaber, Asaad El Bakkari, Soukaina Allioui, Hounayda Jerguigue, Youssef Omor, Rachida Latib
iraetc med. bull; 2(1) 1-3
DOI
Breast cancer in men is a rare pathology. Among all breast cancers, less than 1 percent affect men. It is often unsuspected in men who generally hesitate to seek medical attention, which delays diagnosis and treatment. It generally presents the same risk factors and therapeutic modalities as in women, but still has some clinical and radiological particularities. In this study, we describe the typical radiological appearance of breast cancer in men, as visualized through our case from the department, to identify the radiological particularities of male breast cancer, thus facilitate early diagnosis and knowledge of differential diagnoses to avoid unnecessary biopsies. The ultrasound-mammography combination is the gold standard, followed by a biopsy for histological confirmation. The tumor is often retro-areolar, and any excentric location is suspicious of malignancy. Mammography rarely shows microcalcifications, unlike in women. Ultrasound allows for a positive diagnosis by guiding the biopsy, evaluating extension to the pectoral muscle, and establishing differential diagnoses. MRI is not indicated in male subjects. Invasive ductal carcinoma constitutes the majority of cases. The Treatment consists of a mastectomy in combination with other therapeutic modalities such as hormone therapy, radiotherapy, and chemotherapy. Conservative treatment has no place in men. The prognosis is bleaker than in women due to diagnostic delay caused by neglect and lack of understanding of the disease by men.
Majedul Hoque
iraetc med. bull; 2(1) 4-6
DOI
Rezafungin is a novel long-acting echinocandin licensed by the US Food and Drug Administration for the treatment of invasive candidiasis and candidaemia. A novel inhibitor of -glucan synthase, rezafungin possesses a chemical relationship with anidulafungin. It is regarded as the original echinocandin molecule of the current generation. With improved tissue penetration, better pharmacokinetic, phamacodynamic (PK/PD) pharmaco-metrics, and an excellent safety profile, it offers a number of advantages over the FDA-approved echinocandins. Hypokalemia, pyrexia, diarrhea, anemia, vomiting, nausea, hypomagnesemia, stomach pain, constipation, and hypophosphatemia are the most frequent side events of this medicine (incidence 5%). Because of its remarkable half-life, rezafungin is a promising new addition to the antifungal toolbox that may be used as prophylaxis in immunocompromised patients and early hospital discharge for stable patients. This study provides a brief description of the mechanism of action, target, side effect, and metabolism data on rezafungin.
Iftear Kazim Rafi, Md Nasir Uddin
iraetc med. bull; 2(1) 7-11
DOI:
The chemical components found in herbal treatments are referred to as phytochemicals, and they may be classified into several groups such as alkaloids, terpenoids, glycosides, saponins, and flavonoids. Herbal remedies may be used to cure a wide range of conditions and disorders, such as gastrointestinal issues, skin infections, arthritis, migraines, and fatigue, since these phytochemicals are present in them. Compared to conventional medications, herbal medicines are less costly and have less significant side effects. The laws governing herbal medications differ per nation at the moment. This makes it impossible for manufacturers of herbal medicines to provide a standard product for the worldwide market. Therefore, international regulatory bodies and organizations such as the WHO should work together to develop a unified and consistent policy for herbal medicines. In light of the growing need for plant medicines, this study focuses on the significance, advantages, drawbacks, and clinical applications of contemporary herbal drugs.
Sabbir Hossain
iraetc med. bull; 2(1) 12-15
DOI:
Worldwide, the use of herbal medications is becoming more common, particularly among women who are pregnant. According to research done up until December 2012, the prevalence of using herbal medicines during pregnancy ranged from 22.3% to 82.3%, suggesting a growing trend in this regard. The herbs peppermint, ginger, thyme, chamomile, sage, anise, fenugreek, and green tea were most frequently utilized. The most popular uses were for treating symptoms of the flu and gastrointestinal ailments. An overview of the field of herbal medicine is given in this review, along with information on its rules, difficulties, and general safety.
Iftear Kazim Rafi
iraetc med. bull; 2(1) 16-20
https://doi.org/10.62469/tmb.v02i01.005
One of the most common mental conditions and a major contributor to disability is anxiety disorders. While a great deal of research is still being done on depression, schizophrenia, and posttraumatic stress disorder (PTSD), there aren't many new drugs being studied for anxiety disorders. Anxiety is an extreme fear-based biological warning system that gets us ready to take action. It has to be distinguished from the typical terror reaction. Among the most prevalent mental illnesses among children and teenagers, anxiety disorders frequently go undiagnosed or untreated. A variety of characteristics, such as race, sex, the kind of anxiety, and the quality of epidemiological research influences a community's anxiety prevalence. Treatments such as transcranial magnetic stimulation, medication augmentation, and novel pharmaceutical agents like vortioxetine showed mixed results when used to individuals with anxiety disorders who did not respond well to conventional therapies or only partially responded to it. The public should only be offered new anxiety disorder treatment alternatives following a careful assessment of their effectiveness. Integrative teamwork and the management of anxiety disorders in need include cognitive behavioral therapy, mindfulness-based psychotherapies, psychodynamic psychotherapies, and psychopharmacologic treatments.
Mohammad Sabbir Hossain, Arafath Jubayer, Md. Nipatul Hasan Nirob, Md. Sazidul Islam
iraetc med. bull; 2(1) 21-25
https://doi.org/10.62469/tmb.v02i01.006
Consumers' health is impacted by nutraceuticals in a variety of ways biochemically. Beyond their basic nutritional roles, nutraceuticals offer additional advantages. Identifying nutritional deficiencies from other physiological effects, like lowered disease risk, is crucial. Herbal supplements, refined foods, genetically modified foods, and dietary supplements are examples of nutraceuticals. A nutritional supplement survey was conducted in a few areas of the Narsingdi district. In total 210 men and women were enlisted, and the majority of them underwent methodical in-person interviews. This study's main objective was to determine how much knowledge and usage of nutritional supplements there was among people living in rural and urban areas. All findings are presented and clarified in result and discussion section. In summary, this study broadens the current understanding of the pattern of nutraceutical use among Bangladeshi urban and rural populations.